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Vancomycin hydrochloride

盐酸万古霉素
Catalog No.
B1223
窄谱糖肽抗菌剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 454.00
现货
250mg
¥ 472.00
现货
1g
¥ 609.00
现货

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A

背景

Vancomycin hydrochloride is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1485.72
Cas No.1404-93-9
FormulaC66H76Cl3N9O24
Solubility≥55.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; ≥22.15 mg/mL in H2O
SDFDownload SDF
运输条件 蓝冰运输或根据您的需求运输。
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试验操作

Animal experiment:[1]

Animal models

C57BL/6 mice challenged with Clostridium difficile (C. difficile) strain VPI 10463

Dosage form

20 mg/kg

Once daily by oral gavage for 5 days

Applications

Vancomycin treatment of infected mice was associated with improved clinical, diarrhea, and histopathology scores and survival during treatment. However, after discontinuation of the drug, clinical scores and histopathology were worse in treated mice than in untreated infected controls. Decreasing the duration of vancomycin treatment from 5 days to 1 day decreased recurrence and deaths in C. difficile infection.

Note

The technical data provided above is for reference only.

References:

1. Warren CA, van Opstal EJ, Riggins MS, et al. Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrobial Agents and Chemotherapy, 2013, 57(2): 689-696.

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