UK 383367
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
UK 383367是一种新型的原胶原C-蛋白（PCP）抑制剂。被研究用于治疗手术后皮肤疤痕，可以有效抑制PCP的活性，IC50值为44 nM，也可作为基质金属蛋白酶（MMP）的选择性抑制剂，对MMP-2的IC50大于60000 nM，MMP-1、MMP-3、MMP-9和MMP-4的IC50大于10,000 nM。UK 383367对磷酸二酯酶-4（PDE-4）也具有弱的抑制作用，但其机制尚不清楚，包括PDE-4a、PDE-4b、PDE-4c和PDE-4d，IC50值分别1.8 μM、1.5 μM、2.4 μM及0.9 μM。
参考文献：
G. A. Allan, J. I. Gedge, A. N. R. Nedderman, S. J. Roffey, H. F. Small and R. Webster. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 2006; 36(5): 399-418
Bailey S,Fish PV,Billotte S,Bordner J,Greiling D,James K,McElroy A,Mills JE,Reed C,Webster R. ff. Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg Med Chem Lett.2008;18(24):6562-6567
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 324.38 |
| Cas No. | 348622-88-8 |
| Formula | C15H24N4O4 |
| Synonyms | UK383367, UK-383367 |
| Solubility | Soluble in DMSO |
| Chemical Name | 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1CCC(CC1)CCCC(CC(=O)NO)C2=NC(=NO2)C(=O)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | UK 383367是BMP-1的有效选择性抑制剂，IC50值为44 nM。 | |||||
| 靶点 | BMP-1 | |||||
| IC50 | 44 nM | |||||
化学结构
