UC 112
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
UC-112（5-((苄氧基)甲基)-7-(吡咯烷-1-亚甲基)喹啉-8-醇）是细胞凋亡蛋白抑制剂（IAP）的抑制剂。[1]
细胞凋亡蛋白抑制剂（IAP）家族在多数人类癌细胞中过表达，但在成人已分化的组织中几乎不表达。细胞凋亡蛋白抑制剂（IAP）被广泛认为是有希望的耐药性肿瘤的药物靶点。[1，2]
UC-112可强力活化caspase-3/7和caspase-9活性，并可在低达1 mM的浓度下选择性降低存活水平。UC-112与已知的蛋白酶体抑制剂Z-Leu-Leu-Leu-CHO（MG-132）共孵育可解除survivin抑制。在A375人类黑色素瘤异种移植模型中，作为单一制剂，UC-112可强力抑制肿瘤生长，减少X染色体关联的IAP和survivin水平。[1]
在体外多个癌细胞系中，UC-112可抑制肿瘤细胞生长，并在体内抑制黑色素瘤肿瘤生长。机理研究表明，UC-112可选择性抑制survivin表达，诱导强烈的癌细胞凋亡。UC-112可下调IAP水平，特别是survivin蛋白，从而有效抑制肿瘤细胞增殖。[1，2]
参考文献：
[1] Wang J, Li W. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29.
[2] Xiao M, Wang J, Lin Z, etal. , Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties. PLoS One. 2015 Jun 12;10(6):e0129807.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 348.44 |
| Cas No. | 383392-66-3 |
| Formula | C22H24N2O2 |
| Solubility | Soluble in DMSO |
| Chemical Name | 5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol |
| SDF | Download SDF |
| Canonical SMILES | OC1=C2C(C=CC=N2)=C(COCC3=CC=CC=C3)C=C1CN4CCCC4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
