Troglitazone
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
过氧化物酶体增殖物激活受体γ(PPARγ)激动剂和PPARg/a双受体激动剂用于治疗2型糖尿病.曲格列酮是一种典型的致肉瘤PPARg激动剂.
体外实验:曲格列酮PPARγ配体对细胞增殖有强效的抑制作用,诱导肾癌(RCC)细胞凋亡,这表明PPARγ配体对肾癌细胞有潜在的抗肿瘤作用[1].
体内实验:在小鼠棕色和白色脂肪组织和肝脏中,致肉瘤剂量(400 和800 mg/kg)的曲格列酮用药4周后可增加内皮细胞(EC)增殖[2].
临床实验:已在脂肪肉瘤和糖尿病患者中进行一些临床实验,来调查曲格列酮的效用\安全性及药代动力学[3].
参考文献：
[1] Yang FG, Zhang ZW, Xin DQ, Shi CJ, Wu JP, Guo YL, Guan YF. Peroxisome proliferator-activated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines. Acta Pharmacol Sin. 2005;26(6):753-61.
[2] Kakiuchi-Kiyota S, Arnold LL, Yokohira M, Koza-Taylor P, Suzuki S, Varney M, Pennington KL, Cohen SM. Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation. Toxicol Pathol. 2011;39(7):1032-45.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 441.54 |
| Cas No. | 97322-87-7 |
| Formula | C24H27NO5S |
| Synonyms | Rezulin;CS-045;Noscal |
| Solubility | insoluble in H2O; ≥20.9 mg/mL in DMSO; ≥3.34 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | 曲格列酮(Troglitazone)(CS-045)是一种PPARγ激动剂. | |||||
| 靶点 | PPARγ | |||||
| IC50 | ||||||
质量控制和MSDS
- 批次:
化学结构
