TR-14035
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TR-14035是α4β7/α4β1整合素的双重拮抗剂。其对α4β7和α4β1的IC50值分别为7 nM和87 nM。具有口服活性[1]。TR14035阻断表达人α4β7或小鼠肠系膜淋巴结淋巴细胞的RPMI-8866细胞与MAdCAM-Ig的结合,IC50值分别为0.1和1 μM[2]。在过敏性哮喘的棕色挪威大鼠模型中,腹腔注射TR-14035 (3 mg/kg) 显着降低气道对5-羟色胺 (5-HT) 的高反应性[2]。
参考文献:
[1]. Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10(6):2051-66. PMID: 11937364
[2]. Egger LA, et al. Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62. PMID: 12065712
Storage | Store at -20°C |
M.Wt | 474.33 |
Cas No. | 232271-19-1 |
Formula | C24H21Cl2NO5 |
Solubility | ≥48.1 mg/mL in DMSO |
Chemical Name | (S)-2-(2,6-dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid |
SDF | Download SDF |
Canonical SMILES | COC1=C(C(OC)=CC=C1)C2=CC=C(C[C@H](NC(C3=C(Cl)C=CC=C3Cl)=O)C(O)=O)C=C2 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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