Ticagrelor
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ticagrelor是一种新的P2Y12受体拮抗剂[1].
Ticagrelor可拮抗P2Y12受体,抑制血小板上ADP的血栓功能.Ticagrelor在体外可完全抑制血小板凝集.此外,Ticagrelor对人类血小板凝集有剂量依赖的抑制功能.除此之外,Ticagrelor也是一种可口服的\活跃的和可逆的结合拮抗剂.不像其他抑制剂,Ticagrelor可抑制P2Y12受体而不发生代谢转化.另外,Ticagrelor是第一种噻吩并吡啶类抗血小板制剂,且主要由CYP3A4和CYP2C19代谢[1][2].
参考文献：
[1] Zhou D1, Andersson TB, Grimm SW. In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics. Drug Metab Dispos. 2011 Apr;39(4):703-10.
[2] Li Y1, Landqvist C, Grimm SW. Disposition and metabolism of ticagrelor, a novel P2Y12 receptor antagonist, in mice, rats, and marmosets. Drug Metab Dispos. 2011 Sep;39(9):1555-67. doi: 10.1124/dmd.111.039669. Epub 2011 Jun 13.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 522.57 |
| Cas No. | 274693-27-5 |
| Formula | C23H28F2N6O4S |
| Solubility | ≥26.15 mg/mL in DMSO; insoluble in H2O; ≥20.4 mg/mL in EtOH |
| Chemical Name | (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol |
| SDF | Download SDF |
| Canonical SMILES | CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(C5O)O)OCCO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
