Thrombin Receptor Activator for Peptide 5 (TRAP-5)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
凝血酶受体激活肽5(TRAP-5),化学式为C30H50N8O7,多肽序列为NH2-Ser-Phe-Leu-Leu-Arg-COOH,分子量为634.76。凝血因子II(凝血酶)受体是G蛋白偶联受体,参与调节血栓反应。蛋白水解引发受体的激活(1)。在血小板中,凝血酶有助于止血和血栓形成。内皮细胞的PARs参与血管张力和渗透性的调控,在血管平滑肌中,参与调节收缩、增生和肥大。在动脉粥样硬化和心瓣手术后的再狭窄中,PARs参与了促炎反应。近期研究揭示了这种新型受体在肌肉生长、骨细胞的分化和细胞增殖中的作用(2)。在T细胞中, PAR1、PAR2和PAR3的活化诱导了VAV1的酪氨酸磷酸化。PARs的活化也导致ZAP-70和SLP-76酪氨酸磷酸化的增加,这两个蛋白是T细胞受体信号(TCR)的关键蛋白(3)。
Figure1 Formula of Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Figure2 Structure of Thrombin Receptor
参考文献:
1. Bahou WF, Nierman WC, Durkin AS, Potter CL, Demetrick DJ (September 1993). "Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5". Blood 82 (5): 1532–7.
2. Martorell L, Martínez-González J, Rodríguez C, Gentile M, Calvayrac O, Badimon L (February 2008). "Thrombin and protease-activated receptors (PARs) in atherothrombosis". Thromb. Haemost. 99 (2): 305–15.
3. Bar-Shavit R, Maoz M, Yongjun Y, Groysman M, Dekel I, Katzav S (January 2002). "Signalling pathways induced by protease-activated receptors and integrins in T cells". Immunology 105 (1): 35–46.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 634.77 |
Cas No. | 141685-53-2 |
Formula | C30H50N8O7 |
Synonyms | H2N-Ser-Phe-Leu-Leu-Arg-OH |
Solubility | insoluble in EtOH; ≥14.63 mg/mL in H2O; ≥63.5 mg/mL in DMSO |
Chemical Name | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
SDF | Download SDF |
Canonical SMILES | CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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