Thiostrepton
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
噻唑类抗生素Thiostrepton是一种Forkhead box M1（FOXM1）抑制剂，下调FOXM1，从而显著地抑制癌细胞生长。FOXM1是一种转录因子，调节维持基因组稳定性与细胞周期进程相关基因的表达。
体外：在FOXM1抑制相关的各种人癌细胞中，包括白血病细胞、神经母细胞瘤细胞、肝癌细胞、黑色素瘤细胞以及前列腺癌细胞，Thiostrepton抑制转录活性以及FOXM1表达，诱导大量细胞凋亡。Thiostrepton通过FOXM1自身调节机制，结合到FOXM1的启动子位点，从而抑制FOXM1的转录活性[1]。
体内：在人乳腺癌异种移植模型中，Thiostrepton抑制肿瘤生长。在人MDA-MB-231乳腺癌细胞系和HepG2肝癌细胞系异种移植模型中，Thiostrepton纳米胶束抑制肿瘤生长。在经过药物处理的肿瘤中，上述细胞凋亡活性与致癌基因FOXM1的体内抑制相关[1]。
临床试验：到目前为止，暂无可用的临床研究数据。
参考文献：
[1] Gartel AL. Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors. Scientifica (Cairo). 2014;2014:596528.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1664.89 |
| Cas No. | 1393-48-2 |
| Formula | C72H85N19O18S5 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO |
| SDF | Download SDF |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
