Tetrazole
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50值:N/A
Tetrazole是最简单的四唑类家族的化合物,四唑类家族是一类合成的有机杂环化合物,由四个氮原子和一个碳原子组成的五元环构成。通常认为Tetrazoles与羧酸具有相似的特性,因此它们均是良好的生物电子等排体。此外,一些药物制剂,例如氯沙坦和坎地沙坦(血管紧张素Ⅱ受体阻滞剂),被当作tetrazoles。由于tetrazoles和羧酸具有非常相似的质子解离特性,所以通常在药物化学中,tetrazoles被用作羧酸的替代物[1]。
体外实验:测得tetrazole的酸度常数为4.9。六种血管紧张素II受体拮抗剂中的四种在临床上可有效治疗包含tetrazole的高血压。MTT,即二甲基噻唑二苯基溴化四氮唑噻唑蓝,是一种已知的用于量化活细胞呼吸活性的tetrazole。一些tetrazoles也可用于DNA试验[2]。
体内实验:到目前为止,还没有报道过体内数据。
临床试验:到目前为止,还未进行临床试验。
参考文献:
[1]Berner S, Mühlegger K and Seliger H. Studies on the role of tetrazole in the activation of phosphoramidites. Nucleic Acids Res. 1989 Feb; 17 (3): 853–864
[2]Satchell JF and Smith BJ. Calculation of aqueous dissociation constants of 1,2,4-triazole and tetrazole: A comparison of solvation modelsy. Phys Chem Chem Phys. 2002; 4: 4314-8.
Storage | Store at -20°C |
M.Wt | 70.1 |
Cas No. | 288-94-8 |
Formula | CH2N4 |
Solubility | ≥13.1 mg/mL in DMSO; ≥22.8 mg/mL in EtOH; ≥28 mg/mL in H2O |
Chemical Name | 2H-tetrazole |
SDF | Download SDF |
Canonical SMILES | C1=NNN=N1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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