Teriflunomide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 270.21 |
Cas No. | 108605-62-5 |
Formula | C12H9F3N2O2 |
Solubility | insoluble in H2O; ≥13.5 mg/mL in DMSO; ≥2.54 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | (Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide |
SDF | Download SDF |
Canonical SMILES | CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Cell experiment:[1] | |
Cell lines |
Human synoviocytes |
Reaction Conditions |
10-7 ~ 10-4 M teriflunomide for 50 h incubation |
Applications |
Teriflunomide inhibited the production of prostaglandin E2 in TNF-α- or IL-1α-stimulated isolated human synoviocytes (IC50s = 7 and 3 μM, respectively). At higher concentrations (> 10 μM), teriflunomide also reduced the production of matrix metalloproteinase 1 and IL-6 due to the known inhibitory effect of teriflunomide on pyrimidine synthesis, which could be reversed by the addition of uridine. |
Animal experiment:[2] | |
Animal models |
Male Dark Agouti (DA) rat, 6-week old |
Dosage form |
3 and 10 mg/kg Once daily by oral route |
Applications |
Teriflunomide (3 and 10 mg/kg) delayed disease onset and decreased neurological deficits in a rat model of experimental autoimmune encephalomyelitis induced by complete Freund’s adjuvant and Mycobacterium tuberculosis. |
Note |
The technical data provided above is for reference only. |
References: 1. Burger D, Begué-Pastor N, Benavent S, et al. The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes. Rheumatology (Oxford), 2003, 42(1): 89-96. 2. McMonagle-Strucko K. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Journal of Neurology, 2009, 256(1): 89-103. |
质量控制和MSDS
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