TCS PIM-1 1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TCS PIM-11是一种选择性的Pim-1抑制剂,IC50值为50 nM [1]。
Pim-1是一种原癌基因丝氨酸/苏氨酸-蛋白激酶,在细胞周期进程、细胞凋亡、转录激活和许多基本信号转导途径中具有重要作用。Pim-1的过表达与许多人类癌症相关[2]。
TCS PIM-11是一种有效的Pim-1抑制剂,对Pim-1的选择性比对Pim-2高。晶体结构显示,TCS PIM-11是最有效的Pim-1抑制剂,对Pim-1的抑制活性比对Pim-2强 [1]。
参考文献:
[1]. Cheney, I.W., et al., Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett, 2007. 17(6): p. 1679-83.
[2]. Cen, B., et al., The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol, 2014. 34(13): p. 2517-32.
Physical Appearance | A solid |
Storage | Store at 4°C |
M.Wt | 367.2 |
Cas No. | 491871-58-0 |
Formula | C18H11BrN2O2 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO |
Chemical Name | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile |
SDF | Download SDF |
Canonical SMILES | O=C1C(C#N)=C(C2=CC=CC=C2)C=C(C3=C(O)C=CC(Br)=C3)N1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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