TCS JNK 6o
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TCS JNK 6o对JNK1和JNK2的IC50值分别为45 nM和160 nM[1]。
TCS JNK 6o是一种ATP竞争性的c-Jun氨基末端激酶(JNK)选择性抑制剂。JNKs属于丝裂原活化蛋白激酶(MAP激酶)家族,响应于各种刺激,包括紫外线照射、细胞因子、渗透压休克以及热休克。JNKs在细胞凋亡与T细胞分化途径中起着重要作用。
体外:CS JNK 6o呈剂量依赖性地抑制c-Jun磷酸化(EC50 = 920 nM),抑制胶原诱导的血小板聚集。10 μM CS JNK6o完全或部分地抑制低浓度胶原(0.2 μg/ml和0.5 μg/ml)诱导的血小板聚集,而TCS JNK 6o对高浓度胶原(5 μg/ml)诱导的血小板聚集无效[2]。
体内:在Sprague-Dawley大鼠中,进行TCS JNK 6o的药物代谢动力学研究。TCS JNK 6o具有约为1小时的半衰期,同时显示出极低的生物利用度和极高的清除率。微粒体孵育实验表明,TCS JNK60被迅速地氧化代谢[1]。
临床试验:到目前为止,暂无可用的临床研究数据。
参考文献:
[1] Szczepankiewicz BG1, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.
[2] Kauskot A, Adam F, Mazharian A, Ajzenberg N, Berrou E, Bonnefoy A, Rosa JP, Hoylaerts MF, Bryckaert M. Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J Biol Chem. 2007 Nov 2;282(44):31990-9.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 356.38 |
Cas No. | 894804-07-0 |
Formula | C18H20N4O4 |
Solubility | Soluble in DMSO |
Chemical Name | N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide |
SDF | Download SDF |
Canonical SMILES | O=C(CC1=CC(OC)=CC=C1OC)NC2=NC(OCC)=C(C#N)C(N)=C2 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
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