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TCS JNK 5a

现货
Catalog No.
B3275
JNK2和JNK3抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 880.00
现货
10mg
¥ 680.00
现货
25mg
¥ 1,360.00
现货

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Background

TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 with pIC50 values of 6.7 and 7.5, respectively [1].

c-Jun N-terminal kinases (JNK) belong to the mitogen-activated protein kinase (MAPK) family. JNK1 and JNK2 are widely expressed, whereas JNK3 is mainly expressed in the brain and plays an important role to mediate neurodegeneration such as Alzheimer’s Disease and Parkinson’s Disease [1].

TCS JNK 5a is a selective JNK2 and JNK3 inhibitor. TCS JNK 5a exhibited selective against JNK1 and p38α with pIC50 values of 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α, respectively. Also, TCS JNK 5a was inactive at EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0 [1].

Reference:
[1].  Angell RM, Atkinson FL, Brown MJ, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett, 2007, 17(5): 1296-1301.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt332.42
Cas No.312917-14-9
FormulaC20H16N2OS
Solubility≥16.6mg/mL in DMSO
Chemical NameN-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
SDFDownload SDF
Canonical SMILESC1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

生物活性

Description TCS JNK 5a(JNK抑制剂IX)是一种JNK2和JNK3选择性抑制剂,pIC50值分别为6.7和7.5
靶点 JNK3 JNK2        
IC50 (pIC50=6.5) (pIC50=6.7)        

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