TCS JNK 5a
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TCS JNK 5a是一种JNK2和JNK3选择性抑制剂,pIC50值分别为6.7和7.5[1].
c-Jun N-端激酶(JNK)属于丝裂原活化蛋白激酶(MAPK)家族.JNK1和JNK2广泛表达,而JNK3主要在脑部表达,对介导如阿尔茨海默病和帕金森病的神经退行性疾病中起着重要的作用[1].
TCS JNK 5a是一种JNK2和JNK3选择性抑制剂.与JNK1和p38α相比,TCS JNK 5a对JNK2和JNK3具有选择性,对JNK3\JNK2\JNK1和p38α的pIC50值分别为6.7\6.5\＜5.0和＜4.8.同时,TCS JNK 5a对ErbB2\VegFr2\Src\Tie-2\Alk5\c-Fms\CDK-2\GSK3β和PLK1都没有活性,pIC50值＜5.0[1].
参考文献：
[1]. Angell RM, Atkinson FL, Brown MJ, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett, 2007, 17(5): 1296-1301.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 332.42 |
| Cas No. | 312917-14-9 |
| Formula | C20H16N2OS |
| Solubility | ≥16.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | TCS JNK 5a(JNK抑制剂IX)是一种JNK2和JNK3选择性抑制剂,pIC50值分别为6.7和7.5 | |||||
| 靶点 | JNK3 | JNK2 | ||||
| IC50 | (pIC50=6.5) | (pIC50=6.7) | ||||
质量控制和MSDS
- 批次:
化学结构
