TCS 21311
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TCS 21311是一种有效的和选择性的JAK3抑制剂,IC50值为8 nM。相较于JAK1、JAK2和TYK2,TCS 21311对JAK3显示出高选择性,对JAK1、JAK2和TYK2的IC50值分别为1017、2550和8055 nM。TCS 21311还抑制GSK-3β、PKCα和PKCθ,IC50值分别为3、13和68 nM [1]。
Janus激酶(JAK)是细胞质蛋白酪氨酸激酶的小家族,包括JAK1、JAK2、Tyk2和JAK3,其通过酪氨酸磷酸化转录激活蛋白(STAT),在起始细胞因子触发的信号事件中起关键作用[2]。由于其与相关细胞因子信号传导途径的相关性,JAK3可以作为治疗干预自身免疫性疾病、炎性疾病和器官移植排斥的重要靶标[2]。
参考文献:
Thoma G, Nuninger F, Falchetto R, et al. Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family[J]. Journal of medicinal chemistry, 2010, 54(1): 284-288.
Clark M P, George K M, Bookland R G, et al. Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3)[J]. Bioorganic & medicinal chemistry letters, 2007, 17(5): 1250-1253.
Physical Appearance | Yellow solid |
Storage | Desiccate at RT |
M.Wt | 526.51 |
Cas No. | 1260181-14-3 |
Formula | C27H25F3N4O4 |
Solubility | <52.65mg/ml in DMSO |
Chemical Name | 3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione |
SDF | Download SDF |
Canonical SMILES | CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
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