TCS 2002
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TCS 2002是一种有效的GSK-3β抑制剂，IC50值为35 nM[1]。
糖原合酶激酶-3（GSK-3）是一种丝氨酸/苏氨酸蛋白激酶，磷酸化靶蛋白上的丝氨酸或苏氨酸残基。GSK3β在神经元细胞发育、能量代谢和体节形成方面具有重要作用。
TCS 2002是一种有效的GSK-3β抑制剂，IC50值为35 nM。(S) -TCS 2002和(R) -TCS 2002抑制GSK-3β的IC50值分别为34和140 nM。TCS 2002具有良好的生物利用度（F =40％）和溶解性（38 μg/mL）。(S) -TCS 2002在浓度高达10 μM时，对12种酪氨酸激酶和10种丝氨酸/苏氨酸激酶均没有抑制活性，表明(S) -TCS 2002是一种高选择性的GSK -3β抑制剂[1]。
在小鼠中，冷水压力（CWS）诱导GSK -3β对tau的超磷酸化（如S199、Thr205、Thr231和Ser396）。而(S) -TCS 2002显著抑制35％的tau磷酸化[1]。
参考文献：
[1]. Saitoh M, Kunitomo J, Kimura E, et al. 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J Med Chem, 2009, 52(20): 6270-6286.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 338.38 |
| Cas No. | 1005201-24-0 |
| Formula | C18H14N2O3S |
| Solubility | <33.84mg/ml in DMSO; <8.46mg/ml in ethanol |
| Chemical Name | 2-methyl-5-(3-(4-(methylsulfinyl)phenyl)benzofuran-5-yl)-1,3,4-oxadiazole |
| SDF | Download SDF |
| Canonical SMILES | O=S(C)C1=CC=C(C=C1)C2=COC3=CC=C(C4=NN=C(C)O4)C=C23 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
