Tazarotene
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Tazarotene(乙炔类视黄酸)是第三代处方外用视黄酸。被批准用于治疗牛皮癣、痤疮和受损皮肤[1]。
Tazarotene作为视黄酸的前体药物,在人与动物体内通过迅速脱酯化可以转化为游离酸形式。Tazarotenic酸对(RAR)-β和(RAR)-γ具有选择性,Tazarotenic可以结合到视黄酸受体(RAR)家族全部的(三类)成员上,可能会改变基因表达。
Tazarotene通过调节基因转录来调节这些影响。检查五个非小细胞肺癌(NSCLC)细胞系和五个头颈部鳞状细胞癌(HNSCC)确定Tazarotene是否与反式视黄酸(all-trans retinoic acid, ATRA)的反应有关。在大多数反应的细胞中,在6到12 h内,ATRA诱导Tazarotene-诱导的基因3产生mRNA。根据细胞系的不同, Tazarotene-诱导的基因3产生的ATRA浓度在1到500 nM之间[2]。
67名面部有痤疮的、年龄从13到30岁的患者,参加一项评估外用0.1%的Tazarotene霜治疗面部痤疮的安全性和有效性的研究。要求病人在痤疮部位外敷一层Tazarotene霜(0.1%),每天晚上一次,连续12周。在第2周、第4周、第8周和第12周持续跟进一下。结果显示,53%的患者得到了缓解,9%的患者有了好转,34%的患者有不良反应,4%的患者在12周的治疗中没有反应。对痤疮患者外用Tazarotene霜(0.1%)是一种有效安全的治疗方法[3]。
参考文献:
[1]. Orlandi A ,Bianchi L, Costanzo A, et al. Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazarotene. Journal of Investigative Dermatology, 2004, 122(4): 1037-1041.
[2]. Higuchi E, Chandraratna RAS, Hong, WK, et al. Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype. Oncogene, 2003, 22(30): 4627-4635.
[3]. Zakaria AS, Paul HK, Rahman MA George S K, et al. Topical tazarotene cream (0.1%) in the treatment of facial acne: an open clinical trial. Bangladesh Med Res Counc Bull, 2010, 36(2): 43-46.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 351.46 |
Cas No. | 118292-40-3 |
Formula | C21H21NO2S |
Solubility | insoluble in H2O; ≥11.1 mg/mL in EtOH with ultrasonic; ≥14.85 mg/mL in DMSO |
Chemical Name | ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate |
SDF | Download SDF |
Canonical SMILES | CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次: