Tariquidar methanesulfonate, hydrate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Tariquidar methanesulfonate，hydrate是一种有效的P-糖蛋白（Pgp）抑制剂，非竞争性地抑制与Pgp相关的基底ATPase活性。Pgp是一个170-kDa的转膜蛋白，作为药物外排泵，将结构上不相关的化合物运出细胞。
Tariquidar的化学结构中包含叔胺，二甲氧基和酰胺基，这些结构有助于其对Pgp的抑制作用。三个不同模型的体外实验表明，tariquidar抑制Pgp的IC50范围介于15到223 nM之间。然而，tariquidar在肿瘤细胞系（其多药耐药性是由多药耐药相关蛋白介导的）中的抑制作用是Pgp特异性的，且减弱的。
参考文献：
1. Fox E, Bates SE. Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. Expert Rev Anticancer Ther. 2007 Apr;7(4):447-59.
2. Bankstahl JP, Bankstahl M, Rmermann K, Wanek T, Stanek J, Windhorst AD, Fedrowitz M, Erker T, Müller M, Lscher W, Langer O, Kuntner C. Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study. Drug Metab Dispos. 2013 Apr;41(4):754-62. doi: 10.1124/dmd.112.049148. Epub 2013 Jan 10.
| Storage | Store at -20°C |
| M.Wt | 892.99 |
| Cas No. | 625375-83-9 |
| Formula | C40H52N4O15S2 |
| Synonyms | XR 9576;XR-9576;XR9576 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥56.2 mg/mL in DMSO |
| Chemical Name | N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide;methanesulfonic acid;trihydrate |
| SDF | Download SDF |
| Canonical SMILES | COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC.CS(=O)(=O)O.CS(=O)(=O)O.O.O.O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
相关生物数据
相关生物数据
