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Tandospirone

现货
Catalog No.
B1199
抗焦虑和抗抑郁药
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 1,050.00
现货
10mg
¥ 900.00
现货
50mg
¥ 4,090.00
现货

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Background

Tandospirone (SM-3997; sediel ) is an anxiolytic and antidepressant [1].

Tandospirone has been reported to produce a significant increase in number of shocks at doses of 5 and 10mg/kg, i .p. or 20 and 40 mg/kg, p.o.. 10mg/kg, i.p. of Tandospirone has been revealed to produce a significant increase in the number of shocks following the repeated treatment for 5 or 10 days. In addition, has been noted to impair rota-rod performance at relatively high doses with ED50 values of 207 mg/kg, p.o. and 300mg/kg, p.o. in mice and rats, respectively. Besides, Tandospirone has been evaluated to enhance the duration of the hexobarbital-induced anesthesia with an ED50 value of 212mg/kg, p.o. [1].

References:
[1] Shimizu H1, Hirose A, Tatsuno T, Nakamura M, Katsube J. Pharmacological properties of SM-3997: a new anxioselective anxiolytic candidate. Jpn J Pharmacol. 1987 Dec; 45(4):493-500.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt383.49
Cas No.87760-53-0
FormulaC21H29N5O2
Solubility≥38.3mg/mL in DMSO
Chemical Name(3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
SDFDownload SDF
Canonical SMILESO=C([C@@]1([H])[C@@](C([H])([H])C2([H])[H])([H])C([H])([H])[C@@]2([H])[C@]13[H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C5=NC([H])=C([H])C([H])=N5)C([H])([H])C4([H])[H])C3=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

化学结构

Tandospirone