TAK-700 (Orteronel)
Catalog No.
A4326
人17,20-裂解酶抑制剂
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TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3.
1. Guengerich FP, Wilkey CJ, et al. "Conformational selection dominates binding of steroids to human cytochrome P450 17A1." J Biol Chem. 2019
Jun 28;294(26):10028-10041. PMID:31072872
2. Gonzalez E, Guengerich FP. "Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1." J Biol Chem. 2017 Jul 6. pii: jbc.M117.794917. PMID:28684414
3. F. Peter Guengerich,Martin Egli,et al."The Kinetic and Chemical Mechanisms of Human Cytochrome P450 17A1." Vanderbilt University. 2017 May.
2. Gonzalez E, Guengerich FP. "Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1." J Biol Chem. 2017 Jul 6. pii: jbc.M117.794917. PMID:28684414
3. F. Peter Guengerich,Martin Egli,et al."The Kinetic and Chemical Mechanisms of Human Cytochrome P450 17A1." Vanderbilt University. 2017 May.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 307.35 |
| Cas No. | 426219-18-3 |
| Formula | C18H17N3O2 |
| Solubility | insoluble in H2O; ≥11.2 mg/mL in DMSO; ≥11.93 mg/mL in EtOH with ultrasonic |
| Chemical Name | 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(NC)C1=CC=C2C(C=CC(C3(O)C4=CN=CN4CC3)=C2)=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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