TAI-1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TAI-1是第一类高度有效的Hec1抑制剂.
TAI-1的GI50值为13.48 nM(K562细胞),相比INH1(GI50 =11.7 μM)有效性提高了近1000倍.TAI-1对广谱的肿瘤细胞具有强力的抑制能力.TAI-1可阻断Hec1-Nek2蛋白相互作用,引发Nek2降解,在细胞分裂中期诱导显著的染色体错配,并可诱导凋亡性细胞死亡.TAI-1在三阴性结肠癌\乳腺癌和肝癌的体内动物模型中具有口服活性.有效剂量的初步毒性显示对组织重量\体重和血液指数无影响.TAI-1对癌细胞和靶点具有高特异性,对心道hERG无影响.TAI-1在乳腺\白血病和肝癌细胞中可与拓扑替康\阿霉素和紫杉醇协同作用.对TAI-1的敏感性与P53和RB基因的状态有关.在癌细胞中敲除P53和RB可提高对TAI-1的敏感性.
参考文献：
[1]. Huang LY, Lee YS, Huang JJ et al. Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1. J Exp Clin Cancer Res. 2014 Jan 9;33:6. doi: 10.1186/1756-9966-33-6.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 431.51 |
| Cas No. | 1334921-03-7 |
| Formula | C24H21N3O3S |
| Solubility | ≥43.2 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH |
| Chemical Name | 4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)-N-(1-(pyridin-4-yl)vinyl)thiazol-2-amine |
| SDF | Download SDF |
| Canonical SMILES | COC1=CC=C(OC2=CC(C)=C(C3=CSC(NC(C4=CC=NC=C4)=C)=N3)C(C)=C2)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
