T16Ainh - A01
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 416.52 |
Cas No. | 552309-42-9 |
Formula | C19H20N4O3S2 |
Solubility | Soluble in DMSO |
Chemical Name | 2-((5-ethyl-6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide |
SDF | Download SDF |
Canonical SMILES | O=C1N=C(NC(C)=C1CC)SCC(NC2=NC(C(C=C3)=CC=C3OC)=CS2)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
细胞实验 [1]: | |
细胞系 |
兔肺动脉心肌细胞 |
溶解方法 |
在DMSO中的溶解度> 10 mM。为了获得更高浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
反应条件 |
全细胞IC1Ca由具有以下组成的溶液诱发:TEA(20 mM),CsCl(106 mM),HEPES-CsOH(10 mM,pH7.2),BAPTA(10 mM),ATP.Mg(5 mM)和 GTP.diNa(0.2 mM)。向该溶液中加入7.08 mM CaCl2以获得500nM的游离[Ca2+]。洗涤液具有以下组成:NaCl(126 mM),HEPES-NaOH(10 mM,pH7.35),TEA(8.4 mM),葡萄糖(20 mM),MgCl2(1.2 mM)和CaCl2(1.8 mM)。研究T16Ainh-A01(1-30μM)对由500nM游离Ca2+诱发的IC1Ca的作用。 |
应用 |
在兔肺动脉心肌细胞中,T16Ainh-A01(1-30μM)抑制由500nM游离Ca2+激活的全细胞电流。 |
References: [1] Alison J Davis, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01. Br J Pharmacol. 2013 Feb; 168(3): 773–784. |