Sodium Phenylbutyrate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Sodium Phenylbutyrate is a histone deacetylase (HDAC) inhibitor [1].
HDAC, negatively regulating acetylation of histones, plays an important role in acetylation homeostasis which is a major epigenetic mechanism in cancer development and heart dysfunction [1].
In oral squamous cell carcinoma (OSCC) cell lines CAL27, HSC3, and SCC4, a series of doses of Sodium Phenylbutyrate including 1, 2, 4, 8, and 16 mM, inhibited all cell lines in a dose dependent manner, with IC50 values of 4.091, 3.712, and 3.015 mM, respectively. In HSC3 and SCC4 cells treated with 4 or 3 mM Sodium Phenylbutyrate for 12, 48, and 72 h, significant inhibition on cell vitality could be observed in a time dependent manner [2].
In a mouse model with Adriamycin-induced cardiac injury, Sodium Phenylbutyrate (400 mg/kg/day) was i.p. injected one day before and daily after the Adriamycin injection for two days. Sodium Phenylbutyrate substantially reversed the Adriamycin-induced elevation of creatine kinase and serum lactase dehydrogenase activities, and meanwhile, diminished Adriamycin-induced ultrastructual damages of cardiac tissue by more than 70%. In addition, Sodium Phenylbutyrate completely rescued Adriamycin-associated reduction of cardiac functions, and increased cardiac manganese superoxide dismutase (MnSOD) protein and activity [1].
References:
[1]. Daosukho C, Chen Y, Noel T, et al. Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury. Free Radical Biology and Medicine, 2007, 42(12): 1818-1825.
[2]. Qian K, Sun L, Zhou G, et al. Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo. Cancer Biotherapy and Radiopharmaceuticals, 2018, 33(4): 139-145.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 186.18 |
Cas No. | 1716-12-7 |
Formula | C10H11O2·Na |
Solubility | ≥27.65 mg/mL in H2O; ≥50.9 mg/mL in EtOH with ultrasonic; ≥6.3 mg/mL in DMSO |
Chemical Name | sodium;4-phenylbutanoate |
SDF | Download SDF |
Canonical SMILES | C1=CC=C(C=C1)CCCC(=O)[O-].[Na+] |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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