SJB3-019A
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SJB3-019A是一种新型有效的USP1抑制剂，IC50值为0.0781 μM [1]。
泛素特异性蛋白酶1（USP1）是一种去泛素化（DUB）酶，将DNA结合1（ID1）蛋白上的聚泛素链移除。ID1在癌症的增殖和发展中起重要作用，如白血病[1]。
SJB3-019A是一种新型有效的USP1抑制剂。在K562细胞中，SJB3-019A在促进ID1降解和细胞毒性方面的作用比SJB2-043高5倍。在HeLa细胞中，SJB3-019A增加Ub-PCNA 和Ub-FANCD2的水平，降低同源重组活性[1]。
参考文献：
[1]. Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 276.25 |
| Formula | C16H8N2O3 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥10.85 mg/mL in DMSO with gentle warming |
| Chemical Name | 2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=C2OC(C3=CN=CC=C3)=N1)C4=CC=CC=C4C2=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
