Tyrosine Kinase
Receptor tyrosine kinases bind to extracellular ligands/growth factors, which promotes receptor dimerization and autophosphorylation of receptor tyrosine residues. This triggers a cascade of downstream events through phosphorylation of intracellular proteins that ultimately transduce the extracellular signal to the nucleus, causing changes in gene expression. Receptor tyrosine kinases include EGFR/ErbB, PDGFR, VEGFR, FGFR and MET subfamilies etc. Dysfunctions in tyrosine phosphorylation are linked to oncogenic transformation. In additions, various adaptor and effector proteins couple to carboxy-terminal of an active kinase. For instance, binding of the GRB2 adaptor protein activates EGFR and MAPK/ERK signaling.
Non-receptor tyrosine kinases involve many well-defined proteins (e.g. the Src family kinases, c-Abl, and Jak kinases) and other kinases which regulates cell growth and differentiation. For example, Src family kinases are curial for activating and inhibitory pathways in the innate immune response.
- C4281 SR 0987Summary: RORγ的T细胞特异性同种型的激动剂
- C4727 4-methyl ErlotinibSummary: EGFR抑制剂
- C4394 Rp-8-pCPT-Cyclic GMPS (sodium salt)Summary: GMP依赖性蛋白激酶(cGKs)抑制剂
- C4363 Rp-8-bromo-Cyclic GMPS (sodium salt)Summary: cGMP依赖性蛋白激酶(cGK)抑制剂
- C4025 CEP-28122Summary: 间变性淋巴瘤激酶(ALK)抑制剂
- C3677 PD 166326Summary: 受体酪氨酸激酶抑制剂
- C3730 AAL-993Summary: VEGF受体抑制剂
- C3707 GSK2981278Summary: RORγ选择性的反向激动剂
- C5737 JNJ-10198409Summary: 血小板衍生生长因子(PDGF-BB)酪氨酸激酶抑制剂
- C3841 Neoruscogenin中文名: 新鲁斯可皂苷元Summary: 核受体RORα激动剂