TGF-β / Smad Signaling
The TGF-β family is generally classified into two sub-families, TGF-β ligands, and bone morphogenic protein (BMP) ligands. In canonical signaling, receptor activation lead to phosphorylation of a group of transcription factors called Smads. TGF-β ligands bind to type II receptors (TGF-β II) which recruit and phosphorylate type I receptor (TGF-β I) on serine/threonine residues. The TGF-β I then recruits and phosphorylates a receptor regulated Smad (R-Smad). The R-Smad binds to the common Smad (Co-Smad) and forms a heterodimeric complex. This complex then translocates into the cell nucleus where it binds with nuclear co-factors to regulate the transcription of various target genes. Dysregulation of TGF-β/Smad signaling pathway is associated with a number of pathological conditions including fibrosis, cancer, immunodeficiency, diabetes and cardiovascular diseases etc.
- B3709 Midostaurin (PKC412)中文名: 米哚妥林Target: PKC|PKA|KDR|Flk1|PPK|c-Syk|CDK1/CyclinBSummary: PKC抑制剂
- B3688 ML347Target: BMP and Other Activin ReceptorsSummary: 有效的BMP受体选择性抑制剂
- B3687 LDN-212854Summary: BMP受体抑制剂
- B3686 DMH-1Target: BMP and Other Activin ReceptorsSummary: BMP ALK2受体抑制剂
- A8830 ZIP (SCRAMBLED)Summary: PKMζ抑制剂
- B3392 GSK269962ATarget: ROCK|RSK|MSKSummary: ROCK抑制剂
- B2288 Pirfenidone中文名: 吡非尼酮Summary: TGF-β产生的抑制剂
- B2287 LY3649471 CitationSummary: TGF-β I型受体激酶结构域抑制剂
- B2191 Dequalinium Chloride中文名: 地喹氯铵Target: PKC|Calcium-Activated Potassium (KCa) ChannelsSummary: PKC抑制剂
- B1287 Ro 31-8220Target: PKCSummary: Pan-PKC抑制剂