TGF-β / Smad Signaling
The TGF-β family is generally classified into two sub-families, TGF-β ligands, and bone morphogenic protein (BMP) ligands. In canonical signaling, receptor activation lead to phosphorylation of a group of transcription factors called Smads. TGF-β ligands bind to type II receptors (TGF-β II) which recruit and phosphorylate type I receptor (TGF-β I) on serine/threonine residues. The TGF-β I then recruits and phosphorylates a receptor regulated Smad (R-Smad). The R-Smad binds to the common Smad (Co-Smad) and forms a heterodimeric complex. This complex then translocates into the cell nucleus where it binds with nuclear co-factors to regulate the transcription of various target genes. Dysregulation of TGF-β/Smad signaling pathway is associated with a number of pathological conditions including fibrosis, cancer, immunodeficiency, diabetes and cardiovascular diseases etc.
- C4703 1,2-Dipalmitoyl-sn-glycerolSummary: PKC的弱激活剂
- C4717 L-threo-Sphingosine C-18Summary: 蛋白激酶C抑制剂
- C4315 Bisindolylmaleimide VIII (acetate)Summary: 蛋白激酶C(PKC)抑制剂
- C4316 Bisindolylmaleimide IVSummary: 蛋白激酶C(PKC)抑制剂
- C3656 ALK5 Inhibitor II (hydrochloride)Summary: ALK5抑制剂
- C3523 HispidinSummary: 蛋白激酶Cβ抑制剂
- C3243 SafingolSummary: PKC和鞘氨醇激酶抑制剂
- B7807 Netarsudil (AR-13324)Target: ROCKSummary: ROCK抑制剂
- B6096 SIS3中文名: SIS3 盐酸盐Summary: Smad3抑制剂
- B6066 Bisindolylmaleimide VSummary: PKC抑制活性的负对照