Stem Cell - Cancer
In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.
- B5979 CCT251545Summary: WNT信号的具有口服生物利用度的有效抑制剂
- B5833 GSK5032 CitationSummary: EZH2抑制剂
- B4687 iCRT 14Summary: CRT抑制剂
- B4678 CPI-1691 CitationTarget: EZH2|EZH1Summary: EZH2抑制剂
- B2266 LDE225 (NVP-LDE225,Erismodegib)1 Citation中文名: 索尼德吉Target: SmoothenedSummary: Smoothened抑制剂
- B3283 PF-04449913中文名: 格拉吉布Target: SmoothenedSummary: Smoothened拮抗剂
- B2307 LGK-9741 CitationSummary: PORCN抑制剂
- A8685 Wnt-C592 CitationTarget: PORCNSummary: PORCN抑制剂
- A8651 LY2940680Target: Smoothened receptorSummary: Hedgehog / SMO拮抗剂,抑制Hh信号。
- A8340 Cyclopamine1 Citation中文名: 环巴胺Target: SmoothenedSummary: Hedgehog (Hh)信号抑制剂