Stem Cell
In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.
- B5614 Cardionogen 1Summary: Wnt信号传导调节剂
- B5596 ISX 9Summary: 神经发生剂
- B5561 TC-G 24Summary: GSK-3β抑制剂
- B5511 IDE 2Summary: 定形内胚层形成的诱导剂
- B5488 BIO-acetoxime中文名: 6-溴靛玉红-3Summary: GSK-3α/β抑制剂
- B5486 TCS 2002Summary: GSK-3β抑制剂
- B7717 KHS 101 hydrochlorideSummary: 神经元分化诱导剂
- B7700 IQ 1Target: Stem Cell Differentiation|PP2A/Nkd interactionSummary: 维持胚胎干细胞(ESC)的多能性
- B7685 MRT 10Summary: Smoothened(Smo)受体拮抗剂
- B7665 A 1070722Summary: GSK-3抑制剂