Stem Cell
In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.
- B4908 Z-Ile-Leu-aldehydeSummary: 有效的γ-分泌酶抑制剂
- B4818 WAY-262611Summary: β-Catenin 激动剂
- B4793 IM-12Summary: GSK-3β抑制剂
- B5779 CHIR 99021 trihydrochlorideSummary: 糖原合酶激酶3(GSK-3)抑制剂
- B5772 Shz 1Summary: 诱导表型分化
- B5767 GSA 10Summary: Smoothened(Smo)受体激动剂
- B5679 CCT 031374 hydrobromideSummary: 抑制TCF依赖性转录,阻断BIO诱导的β-连环蛋白稳定
- B5674 SMANT hydrochlorideSummary: Smoothened(Smo)信号传导抑制剂
- B5671 JW 67Summary: 经典Wnt通路信号转导的抑制剂
- B5626 KartogeninSummary: 诱导人间充质干细胞分化成软骨细胞