Stem Cell
In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.
- B5979 CCT251545Summary: WNT信号的具有口服生物利用度的有效抑制剂
- B5977 WindorphenSummary: Wnt抑制剂
- B5837 SAGSummary: Hh和Smo激动剂
- B5833 GSK5032 CitationSummary: EZH2抑制剂
- A8709 SW033291Target: 15-PGDHSummary: 15-PGDH酶抑制剂
- B4936 CKI 7 dihydrochloride1 CitationSummary: 酪蛋白激酶1(CK1)抑制剂
- B4925 C34Summary: TLR4抑制剂
- B4924 TA 02Summary: p38 MAPK抑制剂
- B4923 TA 01Summary: CK1ε、CK1δ和p38α抑制剂
- B4922 IWP 4Summary: Wnt/β-catenin信号转导抑制剂