Thrombin - Cell Experiments
Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.
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- A8381 BIBR-1048中文名: 达比加群酯Summary: 凝血酶抑制剂
- A8363 Argatroban中文名: 阿加曲班Summary: 凝血酶介导的纤维蛋白原裂解抑制剂
- A3690 Otamixaban中文名: 奥米沙班Target: Factor XaSummary: 因子Xa抑制剂
- A3381 Edoxaban中文名: 依度沙班Target: Factor XaSummary: 因子Xa抑制剂
- A3126 5-R-Rivaroxaban中文名: 5-R-利伐沙班Target: Factor XaSummary: 因子Xa(FXa)抑制剂
- A4077 BIBR 953 (Dabigatran, Pradaxa)中文名: 达比加群Summary: 强效的、可逆的直接凝血酶抑制剂