Proteases - Calpains
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A4413 PD 150606Target: CalpainsSummary: 非肽类钙蛋白酶抑制剂
- A4412 MDL 28170Target: Cathepsins|CalpainsSummary: Calpain和cathepsin B抑制剂
- A2602 Calpain Inhibitor I, ALLN2 CitationTarget: Cathepsins|CalpainsSummary: Calpain I/II/ B/L抑制剂
- A2576 E-642 CitationTarget: Cathepsins|Calpains|PapainsSummary: 半胱氨酸蛋白酶(cysteine protease)抑制剂
- A2570 Leupeptin, Microbial中文名: 亮抑酶肽Target: Cathepsins|Calpains|TrypsinsSummary: 丝氨酸和半胱氨酸蛋白酶抑制剂