Proteases - Selective
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B4920 EC 144Target: HSP90Summary: Hsp90抑制剂
- B4797 HSP990 (NVP-HSP990)Target: HSP90Summary: HSP90抑制剂
- B7393 GeduninTarget: HSP90Summary: 天然的Hsp90抑制剂
- B5780 UAMC 00039 dihydrochlorideTarget: Dipeptidyl-peptidase IISummary: 二肽基肽酶II(DPP-II)抑制剂
- B4686 TAPI-12 CitationTarget: MMPSummary: TACE/ADAM17抑制剂
- B3941 Talabostat mesylate2 CitationTarget: DPP-4Summary: DPP4抑制剂
- B1037 Alvelestat中文名: 阿维司他Target: NESummary: NE抑制剂
- B3232 Z-IETD-FMK12 CitationTarget: CaspasesSummary: Caspase-8抑制剂
- A8650 Saxagliptin中文名: 沙格列汀Target: DPP-4Summary: DPP4抑制剂
- A8381 BIBR-1048中文名: 达比加群酯Summary: 凝血酶抑制剂