Proteases - Irreversible
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- B3233 Z-LEHD-FMK8 CitationTarget: CaspasesSummary: 不可逆的Caspase-9抑制剂
- B3232 Z-IETD-FMK12 CitationTarget: CaspasesSummary: Caspase-8抑制剂
- A8239 CA-074 Me7 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A8162 E-64-c中文名: 阿洛司他丁酸Target: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- A1923 Z-VEID-FMK2 CitationTarget: CaspasesSummary: Caspase-6抑制剂
- A1921 Z-DQMD-FMK3 CitationTarget: CaspasesSummary: 细胞渗透性Caspase-3抑制剂
- A1920 Z-DEVD-FMK12 CitationTarget: CaspasesSummary: Caspase-3抑制剂
- A1904 Boc-D-FMK1 CitationTarget: CaspasesSummary: 广谱caspase抑制剂
- A1903 E 64d4 Citation中文名: 阿洛司他丁Summary: 半胱氨酸蛋白酶抑制剂