Proteases - Cancer
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B4920 EC 144Target: HSP90Summary: Hsp90抑制剂
- B4797 HSP990 (NVP-HSP990)Target: HSP90Summary: HSP90抑制剂
- B7393 GeduninTarget: HSP90Summary: 天然的Hsp90抑制剂
- B3941 Talabostat mesylate2 CitationTarget: DPP-4Summary: DPP4抑制剂
- B3232 Z-IETD-FMK12 CitationTarget: CaspasesSummary: Caspase-8抑制剂
- A8621 Bestatin hydrochloride中文名: 盐酸乌苯美司Target: AminopeptidasesSummary: 氨肽酶N(APN/CD13)和氨肽酶B抑制剂。
- A2213 17-DMAG (Alvespimycin) HCl1 Citation中文名: 阿螺旋霉素盐酸盐Target: HSP90Summary: Hsp90抑制剂
- A4413 PD 150606Target: CalpainsSummary: 非肽类钙蛋白酶抑制剂
- A4432 ARP 1001 CitationTarget: MMPSummary: MMP-2抑制剂
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂