Proteases - Breast Cancer
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B4920 EC 144Target: HSP90Summary: Hsp90抑制剂
- B7393 GeduninTarget: HSP90Summary: 天然的Hsp90抑制剂
- B3941 Talabostat mesylate2 CitationTarget: DPP-4Summary: DPP4抑制剂
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A4071 Fluorouracil (Adrucil)3 Citation中文名: 氟尿嘧啶Target: Thymidylate SynthaseSummary: 胸苷酸合成酶抑制剂,抗肿瘤药物。
- A4064 NVP-BEP800Target: HSP90Summary: 全合成的HSP90β口服抑制剂
- A4061 IPI-504 (Retaspimycin hydrochloride)3 Citation中文名: 瑞他霉素盐酸盐Target: HSP90Summary: Hsp90抑制剂
- A4056 AT13387Target: HSP90Summary: Hsp90抑制剂
- A4018 YO-01027 (Dibenzazepine, DBZ)1 Citation中文名: 二苯并氮杂卓Summary: γ-分泌酶抑制剂
- A4006 MK-07521 CitationSummary: γ-分泌酶抑制剂