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NAE

NAE (NEDD8-activating enzyme) catalyzes the initial step of the neddylation signaling that regulates CRLs (cullin-ring ubiquitin ligases) activities. Its downstream effect is linked to cancer cell growth and survival.

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 Paper Citing APExBIO Products  Ongoing Clinical Trials  Solubility in DMSO  Solubility in Water  Solubility in Ethanol  Solubility in Dimethyl Formamide
  1. MLN4924
    B1036 MLN4924
     5 Citation
    Target: NAE|Ubiquitin-activating Enzyme E1|SUMOylation
    Summary: NAE抑制剂
      ≥22.2 mg/mL
  2. MLN4924 HCl salt
    A3629 MLN4924 HCl salt
    Target: NAE
    Summary: NAE inhibitor
      soluble in dmso

2 件产品

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