Neuroscience - Animal Experiments
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A3316 Clemizole hydrochloride中文名: 盐酸克立咪唑Target: Histamine H1 Receptors|TRPC channelSummary: H1组胺受体拮抗剂
- A1022 GTP-Binding Protein Fragment, G alphaSummary: GTP结合蛋白片段,Gα,将GTP水解为GDP。
- A1124 Amyloid Beta-Peptide (1-40) (human)1 CitationSummary: β淀粉样蛋白
- C3869 BQCATarget: AChRSummary: M1毒蕈碱乙酰胆碱受体(mAChR)的正变构调节剂
- A1045 Gap 274 CitationTarget: Gap JunctionsSummary: 缝隙连接阻断剂
- A1044 Gap 268 CitationTarget: Gap JunctionsSummary: 间隙连接阻断肽,对应于connexin 43的63-75 aa。
- B4981 SumatriptanTarget: 5-HT1 ReceptorsSummary: 5-HT1受体激动剂
- B4919 Gap191 CitationTarget: Cx43Summary: 选择性连接蛋白43(Cx43)半通道阻断剂
- A1013 Endomorphin-1中文名: 内吗啡肽 1Summary: μ阿片类受体高度有效的选择性激动剂
- B5624 STF 083010Target: Inositol-requiring enzyme 1 (IRE1)Summary: IRE1α核酸内切酶抑制剂