Transferase - Animal Experiments
Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.
- B6062 Manumycin A中文名: 手霉素ASummary: 法尼基转移酶抑制剂
- B5602 GGsTopSummary: γ谷氨酰转肽酶(GGT)抑制剂
- B7417 Tunicamycin1 Citation中文名: 衣霉素Summary: 抗生素,抑制GlcNAc磷酸转移酶(GPT)
- B3703 LB42708Target: FtaseSummary: FTase (法尼基转移酶) 选择性抑制剂
- A4383 Tolcapone中文名: 托卡朋Target: Catechol O-Methyltransferase (COMT)Summary: COMT抑制剂
- A4382 A922500Target: DGATSummary: DGAT-1抑制剂
- A4381 FK866 (APO866)1 Citation中文名: 达珀利奈Target: NamptSummary: NAMPT抑制剂
- A4379 Lonafarnib中文名: 洛那法尼Target: FPTaseSummary: 高效且具有选择性的法尼基转移酶抑制剂