PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
- A4309 GW5015161 CitationSummary: PPARδ的有效选择性激动剂
- A4307 GW0742Summary: PPARδ/β的选择性激动剂
- A4306 Ciprofibrate中文名: 环丙贝特Summary: PPARα激动剂
- A4305 WY-14643 (Pirinixic Acid)1 Citation中文名: 匹立尼酸Target: PPARSummary: 高效的PPARα选择性激动剂
- A4304 Rosiglitazone中文名: 罗格列酮Summary: 有效的PPARγ激动剂
- A4303 GSK3787Summary: PPARβ/δ拮抗剂
- A4302 Rosiglitazone maleate中文名: 马来酸罗格列酮Target: Insulin and Insulin-like ReceptorsSummary: PPARγ激动剂,有效的胰岛素敏化剂
- A4301 T0070907Summary: 有效的人类PPARγ选择性拮抗剂
- A4300 GW96621 CitationSummary: PPARγ拮抗剂