PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
- B1943 Fenofibrate1 Citation中文名: 非诺贝特Summary: PPARα激动剂
- B2117 Pioglitazone中文名: 吡格列酮Summary: PPAR激动剂
- A3893 Troglitazone中文名: 曲格列酮Target: PPARSummary: PPARγ激动剂
- A3536 L-165041Target: PPARSummary: PPARβ/δ选择性激动剂
- A3499 Inolitazone dihydrochlorideSummary: PPARγ激动剂
- A3498 Inolitazone中文名: 伊诺他酮二盐酸盐Summary: PPARγ激动剂
- A3453 GW1929Target: PPARSummary: PPARγ激动剂
- A3216 Balaglitazone中文名: 巴格列酮Summary: PPAR-γ的部分激动剂
- A4324 Pioglitazone HCl中文名: 盐酸吡格列酮Summary: PPARγ激动剂
- A4310 Rosiglitazone HCl中文名: 盐酸罗格列酮Summary: PPARγ激动剂