P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
- C3560 SKF 525A (hydrochloride)中文名: 盐酸普罗地芬,普罗地芬盐酸盐Summary: 细胞色素P(CYP)450抑制剂
- C3471 Omeprazole sulfoneSummary: CYP2C19抑制剂
- C3414 (S)-MephenytoinSummary: 细胞色素P450(CYP)同种型CYP2C19的底物
- B1240 (+)-Ketoconazole中文名: 酮康唑Summary: 细胞色素P450c17的有效抑制剂
- A4318 Avasimibe中文名: 阿伐麦布Target: Acyl coenzyme A: cholesterol acyltransferasesSummary: ACAT抑制剂
- A4316 Ketoconazole中文名: 酮康唑Target: Cytochrome P450 (CYP450)Summary: 环孢菌素氧化酶和睾酮6β-羟化酶的抑制剂
- A4311 PF-4981517Summary: CYP3A4抑制剂
- A4308 Alizarin中文名: 茜草素Summary: 茜素,钙螯合剂,用于染色钙沉积,茜素络合酮用于骨染色,以研究骨重建
- A4240 Abiraterone1 Citation中文名: 阿比特龙Summary: CYP17抑制剂
- A8202 Abiraterone acetate中文名: 乙酸阿比特龙酯Target: Cytochrome P450 (CYP450)Summary: 细胞色素p450 17a1抑制剂