HSP - Cancer
Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.
- A2213 17-DMAG (Alvespimycin) HCl1 Citation中文名: 阿螺旋霉素盐酸盐Target: HSP90Summary: Hsp90抑制剂
- A4388 XL-8881 CitationTarget: HSP90Summary: Hsp90抑制剂
- A4386 Elesclomol (STA-4783)3 Citation中文名: 伊利司莫Summary: 氧化应激/细胞凋亡诱导剂
- A4065 PF-04929113 (SNX-5422)Target: HSP90Summary: Hsp90抑制剂
- A4064 NVP-BEP800Target: HSP90Summary: 全合成的HSP90β口服抑制剂
- A4062 KW-2478Target: HSP90Summary: Hsp90抑制剂
- A4061 IPI-504 (Retaspimycin hydrochloride)3 Citation中文名: 瑞他霉素盐酸盐Target: HSP90Summary: Hsp90抑制剂
- A4060 Geldanamycin2 Citation中文名: 格尔德霉素Summary: 强效的和特异性的Hsp90抑制剂
- A4058 BIIB021Target: HSP90Summary: 选择性竞争性的HSP90抑制剂
- A4057 AUY922 (NVP-AUY922)1 CitationTarget: HSP90Summary: Hsp90抑制剂