Carbonic Anhydrase
Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton. Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).
- B6154 Benzenesulfonamide中文名: 苯磺酰胺Summary: 碳酸酐酶抑制剂
- B6125 Acetazolamide中文名: 乙酰唑胺Summary: 碳酸酐酶(CA)抑制剂
- A4364 Methazolamide中文名: 醋甲唑胺Target: Carbonic AnhydrasesSummary: 碳酸酐酶抑制剂
- A4362 Tioxolone中文名: 噻克索酮Target: Carbonic AnhydrasesSummary: CAI抑制剂
- A4360 Topiramate中文名: 托吡酯Summary: GluR5 受体的拮抗剂,抗惊厥剂
- A4359 Brinzolamide中文名: 布林佐胺Summary: CA II抑制剂
- A4358 U-104Target: Carbonic AnhydrasesSummary: CAIX抑制剂
- A4357 Dorzolamide HCl中文名: 盐酸多佐胺Summary: 碳酸酐酶抑制剂