Membrane Transporter/Ion Channel - Cell Experiments
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B5895 CARIPORIDE中文名: 卡立泊来德Target: NHESummary: 有效的NHE抑制剂
- B4849 Azimilide中文名: 阿齐利特Summary: III类抗心律失常药
- B4798 Procainamide HCl中文名: 盐酸普鲁卡因胺Target: DNA MethyltransferasesSummary: 钠通道阻滞剂
- B5410 AZ 10606120 dihydrochlorideTarget: P2X ReceptorsSummary: P2X7受体拮抗剂
- B7659 Psora 41 CitationTarget: Voltage-gated Potassium (KV) ChannelsSummary: Kv1.3阻断剂
- B7388 Valinomycin中文名: 缬氨霉素Target: IonophoresSummary: 钾离子特异性转运体
- B7335 SB 452533Target: TRPVSummary: TRPV1拮抗剂
- B7113 PSB 06126Target: NTPDasesSummary: NTPDase 3抑制剂
- B6401 PK 111951 CitationTarget: benzodiazepine receptorSummary: 外周苯二氮卓拮抗剂
- B5515 ProTx IITarget: Voltage-gated Sodium (NaV) ChannelsSummary: NaV1.7通道阻断剂