Endocrinology and Hormones - Animal Experiments
There are three types of hormones based on their chemical composition: Amines (e.g. dopamine, adrenalin and noradrenalin); Steroids (e.g. estrogen, testosterone and glucocorticoids); Peptides (e.g. the peptide hormones insulin, ghrelin and vasopressin). Peptide hormones produced by secretory nervous tissue are known as neuropeptides. For example, thyroid hormone plays important parts in development, homeostasis and metabolism, while cortisol is essential for growth, nutrient supply and immune function. Moreover, the regulation of blood glucose involves several pancreatic peptide insulin and its counter regulatory hormone, glucagon, as well as cortisol, growth hormone and epinephrine.
Dysregulations in endocrine system are implicated in diseases such as Acromegaly, Cushing Syndrome, Diabetes, Dwarfism, Graves Disease, Hermaphroditism, Delayed and Precocious Puberty and Thyroid Diseases.
- A1659 Dutasteride中文名: 度他雄胺Target: 5-alpha ReductasesSummary: 5-alpha-还原酶抑制剂
- A5065 Bicalutamide1 Citation中文名: 比卡鲁胺Target: Androgen ReceptorsSummary: 雄激素受体(Androgen receptor)拮抗剂
- A1115 Peptide YY(3-36), PYY, humanTarget: NPY ReceptorsSummary: Y2R激动剂
- A1020 GnRH Associated Peptide (1-13), humanTarget: prolactin secretion|gonadotropin releaseSummary: 催乳素分泌抑制剂
- A8452 ODM-201中文名: 达洛鲁胺Target: Androgen ReceptorsSummary: 新一代雄激素受体抑制剂
- B5469 G-153 CitationTarget: GPR30Summary: GPER受体拮抗剂
- B5455 G-14 CitationTarget: GPR30Summary: GPR30激动剂
- B5421 (Z)-4-Hydroxytamoxifen中文名: 4-羟基他莫昔芬Target: Estrogen and Related ReceptorsSummary: 雌激素受体(ER)调节剂
- B6429 Naltrindole hydrochloride中文名: 纳曲吲哚盐酸盐Summary: δ阿片样物质拮抗剂
- B6269 nor-Binaltorphimine dihydrochlorideSummary: κ-阿片受体拮抗剂