DNA Damage/DNA Repair
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B4896 BMH-21Target: RNA PolymerasesSummary: RNA聚合酶I抑制剂
- B4856 CAY10603Target: Histone Deacetylases (HDACs)Summary: HDAC6抑制剂
- B4879 Blasticidin S HCl中文名: 灭瘟素S盐酸盐Summary: 抗生素,抑制蛋白合成.
- B4872 Mupirocin中文名: 莫匹罗星Summary: 异亮氨酰t-RNA合成酶抑制剂
- B4794 Santacruzamate A (CAY10683)Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- B4745 (S)-10-Hydroxycamptothecin中文名: 羟喜树碱Target: TopoisomerasesSummary: 拓扑异构酶I抑制剂
- B7667 8-ChloroadenosineSummary: 核苷类似物,抑制RNA合成
- B7426 L189Target: DNA LigasesSummary: DNA连接酶 I、III 及IV的抑制剂
- B7337 Compound 401中文名: 化合物401Summary: DNA-PK和mTOR抑制剂
- B6945 DMNBSummary: DNA依赖性蛋白激酶(DNA-PK)抑制剂