DNA Damage/DNA Repair
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- C4327 CBHASummary: HDAC抑制剂
- C4451 Trioxsalen中文名: 三甲沙林Summary: 当用紫外线激活时,嵌入DNA并形成DNA单链加合物及链间交联
- C4433 Luotonin ASummary: 结合并稳定拓扑异构酶I-DNA二元复合物
- C4310 4-amino-1,8-NaphthalimideSummary: PARP抑制剂
- C4305 HNHASummary: HDAC抑制剂
- C4228 Luotonin FSummary: 稳定DNA拓扑异构酶I-DNA复合物
- C3606 NullscriptSummary: HDAC抑制剂scriptaid的阴性对照
- C3166 JW 74Summary: TNKS1/2的催化性PARP结构域的抑制剂
- B7822 AZD0156Summary: ATM激酶抑制剂
- B6186 RHPS41 CitationSummary: 端粒酶抑制剂