PARP
Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.
- A4529 JW 55Summary: PARP结构域抑制剂
- A4528 EB 47Summary: PARP-1抑制剂
- A4527 DR 2313Summary: PARP抑制剂
- A4526 BYK 49187Summary: PARP-1/PARP-2的强效抑制剂
- A4525 BYK 204165Summary: PARP-1的有效选择性抑制剂
- A4524 4-HQN中文名: 4-羟基喹唑啉Summary: PARP抑制剂
- A3958 Veliparib dihydrochloride中文名: 维利帕尼二盐酸盐Target: PARPSummary: PARP-1/PARP-2抑制剂
- A3729 PJ34Target: PARPSummary: PARP-1抑制剂
- A3617 MK-4827中文名: 尼拉帕尼Target: PARPSummary: PARP-1/-2抑制剂
- A3246 BMN-673 8R,9S1 Citation中文名: 他拉唑帕利 (8R,9S)Summary: BMN-673的无活性构型,可作为阴性对照物。