JAK - Cancer
Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.
- A4512 Cucurbitacin I中文名: 葫芦素 ITarget: STAT|JAKSummary: STAT3/JAK2信号转导抑制剂
- A4511 Cercosporamide中文名: 尾孢素酰胺Target: JAK|MNKSummary: Mnk2和JAK3抑制剂
- A3937 XL019Target: JAKSummary: 有效的JAK2选择性抑制剂
- A4152 BMS-911543Target: JAKSummary: JAK2抑制剂
- A4150 WHI-P154Target: VEGFR|Src|EGFR|JAKSummary: JAK3抑制剂
- A4148 NVP-BSK805 2HClTarget: JAKSummary: JAK2抑制剂
- A4147 LY2784544Target: Aurora Kinases|FLT3|VEGFR|FGFR|Trk Receptors|JAK|ALK|TYK2|MUSK|MAP3KSummary: JAK2抑制剂
- A4140 WP1066Target: STAT|JAKSummary: 细胞通透的JAK2/STAT3抑制剂。
- A4137 AZD1480Target: JAKSummary: 新型的ATP竞争性JAK2抑制剂
- A3012 Ruxolitinib (INCB018424)4 Citation中文名: 鲁索替尼Target: JAKSummary: JAK抑制剂